Nexera-e

Comprehensive Two-Dimensional Liquid Chromatograph

Comprehensive 2D-LC methodology is a paradigm shift in liquid chromatography separation. By combining two independent separation modes orthogonally in combination with a dual-loop/dual-valve alternate switching design, the highest possible peak capacity is achieved.
The new Nexera-e is the ideal solution for the separation and characterization of most challenging and complex samples. It is particularly useful for the analysis of pharmaceutical impurities, proteolytic digests, food extracts, natural products and synthetic polymers.

Improved resolving power compared to conventional 1D-LC

How many peaks are co-eluted under one peak? The more complex the sample, along with a high percentage of similar compounds, there exists a high probability of co-eluting compounds found under single peaks.
Even though the co-eluting compounds may not be separated by mono-dimensional separation, an orthogonal two-dimensional system will provide the best possible result.

Comparison of chromatograms (traditional Chinese medicine)

Features

Maximizing the full potential of two separation modes to perform comprehensive two-dimensional separation

Comprehensive 2D-LC is a analytical methodology combining two independent separation modes orthogonally, greatly increasing separation efficiency.
Simultaneous detection in positive and negative mode

Shimadzu triple quadrupole mass spectrometers (TQMS) have the world-class polarity reversal speed (5 ms) and data capture speed (1.5 ms). In comprehensive 2D-LC analysis, the analysis time of second dimension is short, therefore the high-speed performance of the LC-MS affects the quality of the data.
Easy setting of 1D and 2D analysis parameters

Comprehensive 2D-LC often requires complicated software operation for setting 1D and 2D analytical conditions. LabSolutions provides an easy parameter setting and contributes to the simple operation.

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Videos

Nexera-e (Comprehensive Two-Dimensional Liquid Chromatograph)

Liquid Chromatography

Gas Chromatograph-Mass Spectrometry
Comprehensive 2DLC: Concepts, Potential, Applications

Liquid Chromatography

Gas Chromatograph-Mass Spectrometry

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