LCMS-8050 - Options

High Performance Liquid Chromatograph Triple Quadrupole Mass Spectrometer

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Ionization Unit

Designed without cables or tubes, removing the new ionization unit is simple: release a one-touch lever to open the unit and lift it out. In addition, no tools are needed to detach the needles fitted in APCI and DUIS units, allowing for easy maintenance.

LCMS-8050 Upgrade to LCMS-8060

Enhanced performance for the LCMS-8050

The world’s greatest sensitivity and ultra-fast technologies found in the LCMS-8060 are now available for the 8050.

The LCMS-8050 Upgrade Kit includes three key components. Upon installation, the LCMS-8050 will deliver LCMS-8060 performance.

  1. Improved ion sampling efficiency   DL (Desolvation Line)
  2. Improved ion guide with enhanced focusing capabilities  UF-Qarray Enhanced vacuum efficiency
  3. Improved the CID efficiency  Rotary pump

Development of UF-Qarray Ion Guide using Shimadzu’s Simulation Technologies

The new UF-Qarray was designed to maximize sensitivity without compromising robustness or changing the minimal noise performance established in our previously patented Qarray. To optimize the design of the UF-Qarray, a number of simulation studies were carefully conducted using two platforms to model ion behavior under increased gas flow in the low vacuum region. FLUENT software was used to determine which pole shape would maximize ion focusing under gas flows generated by the enhanced pumping configuration (Fig. 1). The second technology, newly developed Optdesign modelling software, was used to analyze the complex behavior of ion trajectories when voltages are applied to the expanded ion cloud (Fig. 2). Using FLUENT and Optdesign simulation models, several prototypes were developed for testing, which led to the UF-Qarray pole geometry final design. This design ejects neutral gas particles in order to reduce noise while achieving greater ion focusing than the previous Qarray design.

Fig. 1 Gas Flow Simulation Results Using FLUENT

Fig. 2 Ion Trajectory Simulation Results Using Optdesign

Groundbreaking Technology for High Sensitivity

With the newly designed UF-Qarray, improved ion focusing efficiency results in greater signal intensity and a reduction in noise. By improving the ion sampling device (desolvation line) and the ion guide (UF-Qarray), and enhancing the vacuum efficiency, the LCMS-8060 defines sensitivity. These new technologies allow for improvements in sensitivity and robustness in all acquisition modes.

Application Specific LC-MS Systems

LC-MS Software

  • Peakintelligence™
    Peakintelligence™
    • LC-MS Software
    Optional software for the LC/MS/MS Method Packages for Primary Metabolites and Cell Culture Profiling
  • LabSolutions Insight
    LabSolutions Insight
    • LC-MS Software
    • GC-MS Software
    • Software Options
    Due to increasingly sophisticated automation, large quantities of high-quality mass spectrometer data can be obtained day and night.
  • Traverse MS
    Traverse MS
    • LC-MS Software
    Traverse MS data analysis software is intended for high-speed processing of MRM data acquired with Shimadzu triple quadrupole LCMS systems in the field of targeted metabolomics.

Application Specific GC-MS Systems

  • Multi-omics Analysis Package
    Multi-omics Analysis Package
    • Application Specific GC-MS Systems
    • Application Specific LC-MS Systems
    The Multi-omics Analysis Package, developed for metabolic engineering applications, provides the ability to automatically generate metabolic maps and perform a variety of data analysis for the vast data generated in fields like metabolomics, proteomics and flux analysis.

Labsolutions Series

  • LabSolutions CS
    LabSolutions CS
    • Labsolutions Series
    • GC Software
    • LC Software
    LabSolutions CS features an innovative operating environment and provides complete data management to ensure secure information in networked laboratories.
  • LabSolutions DB
    LabSolutions DB
    • Labsolutions Series
    • GC Software
    • LC Software
    LabSolutions DB has a data management function and is compliant with the ER/ES Regulations. It is optimally configured for customers using a PC.

Software Options

  • LabSolutions Connect
    LabSolutions Connect
    • Software Options
    • LC Software
    LabSolutions Connect can perform everything from execution of the optimization of MRM transitions and interface parameters to checking of the optimization results, creation of method and batch files for quantitative analysis, and quantitative calculations.

LC-MS Consumables

  • nSMOL Antibody BA Kit
    nSMOL Antibody BA Kit
    • LC-MS Consumables
    nSMOL (nano-surface and molecular orientation limited proteolysis) is Shimadzu’s proprietary, innovative technique that enables selective proteolysis of the Fab region of monoclonal antibodies.
  • Micro Volume QuEChERS Kit
    Micro Volume QuEChERS Kit
    • LC-MS Consumables
    This pretreatment kit for human biological samples is intended for the field of forensic medicine.

LC-MS Components & Accessories

  • LDTD Ion Source
    LDTD Ion Source
    • LC-MS Components & Accessories
    The instrument's outstanding design ensures that laser diode thermal desorption and atmospheric pressure chemical ionization (APCI) are performed rapidly on the sample to be analyzed.

Related information

  • LCMS-8060
    LCMS-8060
    • Triple Quadrupole LC-MS/MS
    The LCMS-8060 is a ground breaking innovation in mass spectrometry helping to transform LC/MS/MS data quality by developing a new vision of sensitivity and speed.
  • LCMS-8045
    LCMS-8045
    • Triple Quadrupole LC-MS/MS
    The LCMS-8045 was designed to be robust. The heated ESI probe, high-temperature heating block, heated desolvation line, drying gas, and focusing optics all act to maximize sensitivity and minimize contamination.
  • LCMS-8040
    LCMS-8040
    • Triple Quadrupole LC-MS/MS
    LCMS-8040 incorporates newly improved ion optics and collision cell technology to provide higher multiple reaction monitoring (MRM) sensitivity.
  • LCMS-8060NX
    LCMS-8060NX
    • Triple Quadrupole LC-MS/MS
    The LCMS-8060NX is a triple quadrupole mass spectrometer with world-class sensitivity and detection speeds. It boasts increased robustness and ease of use as well as Analytical Intelligence to maximize your laboratory’s output.
  • nSMOL Antibody BA Kit
    nSMOL Antibody BA Kit
    • LC-MS Consumables
    nSMOL (nano-surface and molecular orientation limited proteolysis) is Shimadzu’s proprietary, innovative technique that enables selective proteolysis of the Fab region of monoclonal antibodies.
  • Multi-omics Analysis Package
    Multi-omics Analysis Package
    • Application Specific GC-MS Systems
    • Application Specific LC-MS Systems
    The Multi-omics Analysis Package, developed for metabolic engineering applications, provides the ability to automatically generate metabolic maps and perform a variety of data analysis for the vast data generated in fields like metabolomics, proteomics and flux analysis.
  • LC/MS/MS Method Package for Bile Acids Ver. 2
    LC/MS/MS Method Package for Bile Acids
    • Application Specific LC-MS Systems
    This Method Package allows comprehensive analysis of 49 Bile Acids from plasma, urine and feces. Bile Acids are essential for cholesterol metabolism and play a key role in absorption of fats in the small intestine. Additionally, they serve as signaling molecules that regulate metabolism.
  • Triple Quadrupole LC-MS/MS Comparison
    Triple Quadrupole LC-MS/MS Comparison
    • Triple Quadrupole LC-MS/MS
    Triple quadrupole mass spectrometry (TQMS) is a versatile tool for quantitative analysis. Experience the excellent performance and robustness of Shimadzu’s LCMS-TQ instruments, which offer a choice of speed, sensitivity and resolution to meet the demands of high-throughput routine analysis and/or more specialized applications. 
      
    Compare Shimadzu’s triple quadrupole LC-MS/MS systems below.