Noviplex Cards

Shimadzu and Novilytic
Simple, Rapid, Reproducible Collection of Plasma

Shimadzu Scientific Instruments has partnered with Novilytic Labs to offer a powerful, new technology for the rapid generation of plasma from whole blood.
NoviplexTM is a simple, powerful tool used to collect a volumetric sample of plasma (2.5 or 5.0 µL) from a non-volumetric application of whole blood in just minutes. An un-measured application of between 20 to 75 µL of whole blood from a finger-stick, mouse tail-bleed (or other source) is all that is required to collect a volumetric plasma sample. Noviplex can be used as a single step, solid-phase method for sample preparation and analyte extraction, eliminating the need for time consuming techniques such as solid phase extraction, centrifugation and evaporation. 

Novilytic offers analytical tools, methods and services for application by investigators working in various segments of the health, biological and environmental sciences. Novilytic specializes in the application of quantitative LC/MS/MS tandem mass spectrometry to provide the researcher with reliable results permitting identification and comparative study of peptides, metabolites, drugs and other biomarkers.

Properties of the Noviplex Card:

  • 99% removal of red blood cells (based on Hb levels in plasma).
  • Plasma sampling volumes of either 2.5 or 5 µL.
  • Inter-card CV of ~1% in plasma collection volume at constant hematocrit (HCT).
  • Inter-card CV of 2% collection volume variation with 20% to 71% HCT
  • Proteins are deposited as a monolayer upon drying.
  • Metabolites are present in the protein monolayer.

Significant advantages of Noviplex Card technology include:

  • Rapid sample preparation for MS-based analysis, while maintaining assay reproducibility and selectivity.
  • Volumetric plasma sample collection using a single drop of whole blood.
  • Specimen volumes as low as 25 µL.
  • Noviplex cards simplify sample preparation. Eliminates need for solvent extraction, centrifugation and evaporation.
  • Exceptional reproducibility independent of hematocrit.

Exploded Diagram of the Noviplex Card:

Schematic of isolation of plasma from whole blood application using Novilytic plasma separator technology (Noviplex Card). Volumetric plasma is generated from an unmeasured application of whole blood in just minutes.


For Research Use Only. Not for use in diagnostic procedures.

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