LC/MSMS Method Package for Lipid Mediators

Ready-to-Use Analytical Condition.

Lipid mediators (bioactive lipids) have important physiological function and have associated with lifestyle related diseases like diabetes and allergy diseases.
This method package provides you a simultaneous analysis method which covers 130 compounds of lipid mediators derived from arachidonic cascade and its derivatives.




UFMS Technology Covers Wide Range of Compounds

ESI negative ionization commonly used for the measurement of fatty acids but in case of cysteinyl leukotrienes, ethanolamides and lactones, ESI positive ionization is preferred due to the higher sensitivity. Traditional LC/MS is limited to single-polarity analysis, but Shimadzu’s UFMS technology allows the LCMS-8040 to perform 15 msec polarity switching, enabling multiple classes of analytes to be analyzed in a single run without compromising data quality.
The compound panel includes 79 compounds derived from arachidonic acid, 12 EPA-derived compounds, 11 DHA-derived compounds, 9 ethanolamides, and 19 other fatty acid-derived compounds.

Correction for Quantitative Value and Retention Time Using 13 Internal Standards

The 130 compounds were divided into 13 groups based on the chemical property and each internal standard was appropriately selected for each group.
It is possible to make the correction of quantitative value and the retention time to help you to make accurate peak identication.

Remarks and Precautions

  1. For Research Use Only. Not for Use in Diagnostic Procedures.
  2. Shimadzu makes no warranty regarding the accuracy of information included in the database or the usefulness of information obtained from using the database.
  3. It is the user’s responsibility to adopt appropriate quality control tests using standard samples to conrm qualitative and quantitative information obtained with this method package.

For Research Use Only. Not for use in diagnostic procedures.

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