HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The new Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.
Great time savings can be achieved in multiple component data analysis, with functions to check multiple chromatograms at once, display results that exceed standard values in a different color, etc. In addition, several report format templates are provided, reducing the time needed for report creation.
Automatic optimization of MS conditions
Simply set the sample in place and enter the sample information, and MRM and interface parameter optimization will be carried out automatically. The optimization results are shown graphically, reducing the time and effort needed for evaluation.
LC/MS/MS Method Packages and MRM Libraries
Several method packages are available for quick method startup. Analysis can begin right away without MRM optimization or tedious method development.
Straightforward pretreatment saves labor
The SIL-40 autosampler series has programmable micro-volume liquid handling capabilities. Apply these sample pretreatment parameters from a simple graphic interface, reducing labor and increasing precision in co-injection, isomerization, etc.
Automatic co-injection with water matches mobile phase conditions, preserving peak shape for early eluters
Software Solutions from Acquisition to Data Review
LabSolutions Connect™ / LabSolutions Insight™
LabSolutions Connect and LabSolutions Insight provide support for the entire analytical workflow, from optimization of MS conditions to data processing, to achieve maximum efficiency.
Project file management made simple
Automatically stay organized with Connect’s file management system. File locations are automatically determined by file type, enabling the technician to carry out analysis or data processing without having to remember file paths. Analyte concentrations and other sample results can be saved as a data processing results file. Multiple processing methods can be used on the same data set, with results stored separately, enabling processing parameter optimization and easy results retrieval.
MRM and ion source optimization
MRM parameters (precursor ion m/z, product ion mz/, voltages) and ion source parameters (gas flow rate, temperature) are automatically optimized. Just one round of comprehensive optimization maximizes sensitivity, taking into consideration polarity, adduct ions, valency etc. The results of this process can be viewed on a graph using the data browser function. The MRM optimization results screen simultaneously displays a chromatogram, a spectrum, and each voltage. From the MRM optimization results screen, check how the signal strength changes with variations in each parameter.
Review screen for MRM optimization simultaneously displays precursor ion, product ion, and voltage results.
Ion source optimization
Review screen for source optimization graphically displays the successive results of each parameter modification.
Simple method creation and batch creation
LabSolutions Connect organizes optimized results in a dedicated database for easy retrieval. Simply select the target compounds from the database to create a method. Existing method files can be read into the database so that all method file information can be managed together. During the creation of sample acquisition batches, the position of vials is shown on the screen so that settings can be applied easily without risk of mistakes. The project management function prevents the user from accidentally overwriting files from a different project.
Batch creation window
Vial positions and sample types are shown graphically.
Method creation window
Simply select the compounds to be analyzed and the method is automatically generated.
Efficient data review
LabSolutions Insight is the ideal environment for sample data review. Toggle between sample and compound review modes based on user preference. The multiple chromatogram display accordingly presents all samples for a particular analyte, or all analytes for a particular sample. All chromatograms can simultaneously be zoomed in or out, or docked in a separate monitor to suit analyst needs.
Color-coded flags enable the reviewer to easily spot problem samples for speedy and accurate processing. Flags can be set for a wide variety of QC parameters, not only for values exceeding limits, but also approaching limits. Use standard report templates or file output for universal laboratory information systems integration.
Multi-chromatogram survey display
Easily carry out peak corrections for multiple chromatograms, and use the flagging function to keep track of samples that need to be checked.