Smart Forensic Database is registered with information for MRM analysis of forensic toxicological substances often involved in poisonings, such as drugs of abuse, phychotropic drugs, pharmaceuticals and pesticides. The Smart Forensic Database enables simultaneous high-sensitivity analysis of approximately 480 compounds by adding information about 285 forensic toxicological substances. The database contains information on retention indices, MRM transitions, collision energies, and confirmation ion ratios, eliminating the need to configure complicated analysis conditions. Furthermore, retention indices are registered for all of the components, enabling easy updating of retention times via the AART (Automatic Adjustment of Retention Time) function.
With GC-MS/MS MRM mode, mass separation is performed in two stages. As a result, background interferences from biological samples are easily separated from the target compounds, and the forensic toxicological substances are detected with improved sensitivity. Thus, it is easy to determine whether biological samples contain forensic toxicological substances, and data analysis times are substantially reduced.
The Smart MRM program creates MRM methods automatically. In multicomponent simultaneous analysis, it is difficult to configure the dwell, event, and loop time-measurement settings in the MRM program. Smart MRM, however, automatically determines the optimal time-measurement settings, and creates a high-sensitivity method. The MRM method is created based on the retention time information for target compounds, using the AART function.
Extensive support for creating MRM methods
Scan data obtained with simultaneous Scan/MRM measurements can be analyzed using the GC/MS Forensic Toxicological Database, which is used to screen for forensic toxicological substances. MRM data can be used for trace quantity analyses of toxicological substances often involved in poisonings, which are registered in the Smart Forensic Database, while the scan data can be used to screen for drugs of abuse using the GC/MS Forensic Toxicological Database, which includes many designer drugs.
| Compound classification |
Number of registered compounds |
|---|---|
| Drugs of Abuse | 51 |
| Psychotropic Drugs | 200 |
| General Drugs | 87 |
| Pesticides | 125 |
| Others | 5 |
| ISTDs | 18 |
| Total | 486 |
| Derivatization classification |
Number of registered compounds |
|---|---|
| Underivatized | 418 |
| TMS derivatized | 59 |
| TFA derivatized | 9 |
| Total | 486 |
The AART method file is registered with analysis conditions suited to the registered compounds. This allows you to start measurements without having to set analysis conditions and data analysis parameters.
The database file is registered with information on up to six transitions per component. In addition, retention indices are registered for all registered compounds, making it possible to create MRM methods from retention times corrected using the AART function.*
* The retention indices registered in the database are calculated using the analysis conditions registered in the AART method file. If you are using the registered retention indices, use the column indicated below, under identical conditions.
Analysis columns
SH-Rxi™-5Sil MS (30 m, 0.25 mm i.d., df=0.25 μm, P/N 221-75954-30) or DB-5ms (30 m, 0.25 mm i.d., df=0.25 μm)
n-alkane
C8-C40 Alkanes Calibration Standard (Sigma-Aldrich®)
Applicable Systems
GC/MS: GCMS-TQ™ series
Operation environment
Workstation software: GCMSsolution™ Ver. 4.31 or later
Excel™: Microsoft® Excel 2010, 2013, 2016 (32bit)
Remarks and Precautions
Smart MRM, GCMS-TQ and GCMSsolution are trademarks of Shimadzu Corporation.
Rxi is a registered trademark of Restek Corporation.
Excel and Microsoft are either registered trademarks or trademarks of Microsoft Corporation in the United States and/or other countries.
Sigma-Aldrich is a registered trademark of Sigma-Aldrich Co. LLC.
For Research Use Only. Not for use in diagnostic procedures.
This page may contain references to products that are not available in your country.
Please contact us to check the availability of these products in your country.
For Research Use Only. Not for use in diagnostic procedures.
This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.
