Ultra High Performance Liquid Chromatograph for Online Dissolution Testing
Taking Online Dissolution Testing Into the New Era
of Ultra High Performance Chromatography
Dissolution tests are widely used in original pharmaceuticals development and quality control and for bioequivalence tests in generic drugs.
The Nexera FV provides substantial labor savings by automating processes ranging from the dispensing of dissolution media to data acquisition and data analysis.
In addition, the system is based on the Nexera X2, renowned for its speed, sensitivity, and stability. Now you can quickly obtain reliable dissolution test results. The Nexera FV can also be used as a standard UHPLC system, ensuring high laboratory throughput.
Provides Labor Savings and Faster Speeds in Dissolution Testing
- A high-efficiency UHPLC offering short analysis times
- Unattended operation for overnight testing
- Automated reporting
Sufficient to Quickly Dissolving Samples Tests
- Handles sampling intervals as short as 5 minutes
- UHPLC analysis ensures quick turn-around of results
Substantial Improvements in Work Scheduling
- By using dedicated software of Nexera FV, the burden of preparing the exam schedule can be drastically reduced.
System Configuration for Online Dissolution Testing
With the Nexera FV, the dissolution tester and the autosampler are connected online, so everything is automated from sampling to dilution to data acquisition and analysis. There is no manual dispensing of samples, ensuring reliable results.
Flow Vials Provide Automated of Dissolution Testing
Dissolution medium from the dissolution tester flows directly into flow vials loaded into the autosampler. A bubble suppression design has been adopted for these flow vials, enabling high-accuracy sampling of dissolution media. Depending on the dissolution tester used, 8 or 12 flow vials can be loaded.
Two Analysis Modes Promote Faster Dissolution Testing
Direct Injection Analysis Mode: Exclusively with the Nexera System
If the analysis of the dissolution sample set finishes before the next sampling time, the medium can be injected directly from the flow vial connected to the dissolution tester, for use in analysis.
Fraction Analysis Mode: For Confirmation of Dissolution Profiles Equivalent with UV Spectrophotometers
This analysis mode is used for tests with very short dissolution sampling intervals. Up to 768 samples can be fractionated. This mode is also effective when dissolution quantities are large and dilution is required. Sampling intervals as short as 5 minutes are realistic.
Reliable Performance Expands the Range of Choices
Compatible with High-Concentration Samples Requiring Dilution
High dissolution quantity samples often require dilution. Samples can be diluted by using the fraction analysis mode. High injection accuracy is provided even at trace quantities, enabling reliable dilution even without manual handling.
The data shows a comparison between a standard liquid (aqueous caffeine solution), with the dilution ratios manually adjusted by an experienced engineer, and a standard liquid automatically diluted by the Nexera FV. This data shows that the system can perform dilution reliably.
|Dilution Ratio (Times)
||Dilution Accuracy (%)
One System Plays Two Roles, Significantly Improving the Throughput of the Testing Lab
The Nexera FV is a multipurpose system for on-line dissolution testing and high-efficiency UHPLC analysis, such as compound screening.
Provides High Cost Effectiveness in Testing Thanks to Consumables with a Long Operating Life
A special septum is used for the flow vial that receives the dissolution medium. It boasts a better degree of adherence after needle penetration in comparison to a regular septum, and can be used for 100 continuous injections without leaking. This greatly reduces maintenance, enabling continuous testing.